This brief summarizes available literature on strategies for trauma-responsive affirming care in a way that is relevant for administrators, managers, and professionals whose work centers youth with experience in the child welfare and juvenile justice systems, youth experiencing homelessness, and opportunity youth. We intend for these strategies to be relevant in both medical settings and youth-supporting organizations. In this brief, we define “trauma-responsive affirming care” as a strengths-based approach that responds to the ways in which traumatic experiences intersect with gender identity and sexual orientation—as well as with other identities such as racial/ethnic identity, socioeconomic status, and immigration status—to impact a person’s needs.